Defining brain mechanisms that control and adapt motivated behavior will not only advance addiction treatment. It will help society see that addiction is a disease that erodes free will, rather than representing a free will that asks for or deserves consequences of drug-use choices. This science has important implications for understanding addiction's comorbidity in mental illness and reducing associated public health and criminal justice burdens.

Cost conversations are essential to informed consent because patients have a right to information that they think is relevant, and patients overwhelmingly report that cost information is relevant to their medical decisions. Providers have an ethical responsibility to provide necessary information for informed consent, and therefore must discuss costs. The Shared Decision Making model is ideal for enabling this exchange of information, and decision aids are also helpful. Although barriers exist, many useful tools can help providers fulfill this obligation, and (...) encouraging progress is being made to improve cost transparency from insurers and facilities. (shrink)

Despite increasing scientific interest in self-generated thought-mental content largely independent of the immediate environment-there has yet to be any comprehensive synthesis of the subjective experience and neural correlates of affect in these forms of thinking. Here, we aim to develop an integrated affective neuroscience encompassing many forms of self-generated thought-normal and pathological, moderate and excessive, in waking and in sleep. In synthesizing existing literature on this topic, we reveal consistent findings pertaining to the prevalence, valence, and variability of emotion in (...) self-generated thought, and highlight how these factors might interact with self-generated thought to influence general well-being. We integrate these psychological findings with recent neuroimaging research, bringing attention to the neural correlates of affect in self-generated thought. We show that affect in self-generated thought is prevalent, positively biased, highly variable (both within and across individuals), and consistently recruits many brain areas implicated in emotional processing, including the orbitofrontal cortex, amygdala, insula, and medial prefrontal cortex. Many factors modulate these typical psychological and neural patterns, however; the emerging affective neuroscience of self-generated thought must endeavor to link brain function and subjective experience in both everyday self-generated thought as well as its dysfunctions in mental illness. (shrink)

In the maximal form of indirect development found in many taxa of marine invertebrates, embryonic cell lineages of fixed fate and limited division capacity give rise to the larval structures. The adult arises from set‐aside cells in the larva that are held out from the early embryonic specification processes, and that retain extensive proliferative capacity. We review the locations and fates of set‐aside cells in two protostomes, a lophophorate and a deuterostome. The distinct adult body plans of many phyla develop (...) from homologous set‐aside cells within homologous larvae. We argue that the stocks from which these phyla arose utilized these respective larvae, and the diversity of their adult body plans reflects diverse pattern formation processes executed in their set‐aside cell populations. Chordates and arthropods develop directly, but share adult characters with indirectly developing phyla. Thus the deuterostome and protostome stocks that were ancestral to chordates and arthropods, respectively, also utilized maximal indirect development. (shrink)

Núñez and colleagues (2019) question whether cognitive science still exists “as a coherent academic field with a well‐defined and cohesive interdisciplinary research program.” This worry may be premature on two grounds. First, we are not convinced that the Lakatosian criterion of coalescence around a core framework is the best standard for judging whether a field is well‐defined and productive. Second, although we acknowledge that cognitive science is not as visible as we would like, we doubt that this low profile accurately (...) reflects the state of actual research and teaching programs based on the cognitive science approach. (shrink)

Núñez and colleagues (2019) question whether cognitive science still exists “as a coherent academic field with a well‐defined and cohesive interdisciplinary research program.” This worry may be premature on two grounds. First, we are not convinced that the Lakatosian criterion of coalescence around a core framework is the best standard for judging whether a field is well‐defined and productive. Second, although we acknowledge that cognitive science is not as visible as we would like, we doubt that this low profile accurately (...) reflects the state of actual research and teaching programs based on the cognitive science approach. (shrink)

This paper critically supports the modern evolutionary explanation of religion popularised by David Sloan Wilson, by comparing it with those of his predecessors, namely Emile Durkheim and Thomas Hobbes, and to some biological examples which seem analogous to religions as kinds of superorganisms in their own right. The aim of the paper is to draw out a theoretical pedigree in philosophy and sociology that is reflected down the lines of various other evolutionarily minded contributors on the subject of religion. The (...) general theme is of evolved large-scale cooperative structures. A scholarly concern is as follows: Wilson draws on Durkheim, using Calvinism as an example without mentioning Hobbes, but it was Thomas Hobbes who used Calvinism as an example of a leviathanesque religious structure—which is not acknowledged by either Wilson or Durkheim. If there are even any similarities between these authors, there appears to be an omission somewhere which should rightly be accounted for by giving credit to Hobbes where it is due. I issue on conclusion, what it is that makes Wilson’s approach radically different to that it skates on. I also issue it with a cautionary word. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

The cause of Paget's disease is still unknown, despite many years of intensive study. During this time, evidence has sporadically emerged to suggest that the disease may result from a slow viral infection by one or more of the Paramyxoviruses. More recently, epidemiologic and molecular studies have suggested that the canine paramyxovirus, canine distemper virus, is the virus responsible for the disease. If true, then along with rabies, this would be a further example of a canine virus causing human disease. (...) Studies in the natural host have now supported these findings. Further investigations have proposed that the bony abnormalities seen in Paget's disease are due to the effects of the virus on osteoclastic interleukin‐6 and c‐FOS production, possibly via the transcription factor NF‐kB. (shrink)

This study investigates the differences in individuals'' ethical decision making between Canadian university business students and accounting professionals. We examine the differences in three measures known to be important in the ethical decision-making process: ethical awareness, ethical orientation, and intention to perform questionable acts. We tested for differences in these three measures in eight different questionable actions among three groups: students starting business studies, those in their final year of university, and professional accountants.The measures of awareness capture the extent to (...) which respondents felt that a particular action was unethical according to each of several ethical criteria. We found few differences between the two student groups on these measures, suggesting that their education had minimal effect on raising their awareness of the ethical issues in the vignettes. Indeed, overall, the graduating student''s scores were marginally lower than those of the entry-level students. However, the professionals viewed some actions as significantly less ethical than did the graduating students. (shrink)

A queue‐jumping argument concludes that some course of action is impermissible by likening it to the presumptively impermissible act of jumping a queue. Arguments of this sort may be found in a disparate range of contexts and in support of policies favoured by both left and right. Examples include arguments against private education and private health care but also arguments against accommodations for learning disabilities, refugee resettlement, and birthright citizenship. We infer that, although queue‐jumping arguments are strictly analogies, they constitute (...) a sufficiently distinct class of arguments to justify their separate treatment. The paper proposes an argumentation scheme for queue‐jumping arguments and demonstrates its applicability to some existing arguments of this type. (shrink)

It is widely suspected that arguments from conceivability, at least in some of their more notorious instances, are unsound. However, the reasons for the failure of conceivability arguments are less well agreed upon, and it remains unclear how to distinguish between sound and unsound instances of the form. In this paper I provide an analysis of the form of arguments from conceivability, and use this analysis to diagnose a systematic weakness in the argument form which reveals all its instances to (...) be, roughly, either uninformative or unsound. I illustrate this conclusion through a consideration of David Chalmers. (shrink)

The development of ethical guidelines and regulations regarding human subjects research has focused upon protection of vulnerable populations by relying on a limited typology of vulnerabilities. This results in several challenges: First, Institutional Review Boards struggle to interpret and apply the regulations because they are often vague and inconsistent. Second, applying the regulations to subjects who fit within multiple categories of vulnerability can lead to contradictions and the rejection of research that would be permissible if only one category were applicable. (...) Finally, some potential subjects have social and other context-based vulnerabilities that are not described in the federal regulations... (shrink)

Methods to facilitate co-production in mental health are important for engaging end users. As part of the Technology for Healthy Aging and Wellbeing initiative we organized two interactive co-production workshops, to bring together older adults, health and social care professionals, non-governmental organizations, and researchers. In the first workshop, we used two activities: Technology Interaction and Scavenger Hunt, to explore the potential for different stakeholders to discuss late life mental health and existing technology. In the second workshop, we used Vignettes, Scavenger (...) Hunt, and Invention Test to examine how older adults and other stakeholders might co-produce solutions to support mental wellbeing in later life using new and emerging technologies. In this paper, we share the interactive materials and activities and consider their value for co-production. Overall, the interactive methods were successful in engaging stakeholders with a broad range of technologies to support mental health and wellbeing and in co-producing ideas for how they could be leveraged and incorporated into older people’s lives and support services. We offer this example of using interactive methods to facilitate co-production to encourage greater involvement of older adults and other under-represented groups in co-producing mental health technologies and services. (shrink)

One of the aspects of consciousness deserving of study is what might be called its subjective unity - the way in which, though conscious experience moves from object to object, and can be said to have distinct ‘states', it nevertheless in some sense apparently forms a singular flux divided only by periods of unconsciousness. The work of William James provides a valuable, and rather unique, source of analysis of this feature of consciousness; however, in my opinion, this component of James’ (...) theory of the mind has so far gone under-emphasized in the scholarly literature. This paper undertakes some philosophical geography, trying to draw out and elucidate some of the relevant ideas from James’ corpus, and also subjects those ideas to some analysis to try and assist in judgements of their current importance. (shrink)

In this article, we develop and defend a new argument for animalism -- the thesis that we human persons are human animals. The argument takes this rough form: since our pets are animals, we are too. We’ll begin with remarks on animalism and its rivals, develop our main argument, and then defend it against a few replies.

Four experiments supported the hypothesis that ordinary people understand free will as meaning unconstrained choice, not having a soul. People consistently rated free will as being high unless reduced by internal constraints (i.e., things that impaired people’s mental abilities to make choices) or external constraints (i.e., situations that hampered people’s abilities to choose and act as they desired). Scientific paradigms that have been argued to disprove free will were seen as reducing, but usually not eliminating free will, and the reductions (...) were because of constrained conscious choice. We replicated findings that a minority of people think lacking a soul reduces free will. These reductions in perceived free will were fully explained by reductions in people’s perceived abilities to make conscious decisions. Thus, some people do think you need a soul to have free will—but it is because they think you need a soul to make conscious decisions. (shrink)

"In the United States, we try to comfort ourselves with the belief that this country, as the leading world power and industrial democracy, is different from the rest of the world--that we have solved our day-to-day problems. Such optimism--undergirded with the best of intentions--obscures the reality of the social problems that remain among us. To name only a few, these include violence, drugs, and other crime illiteracy, homelessness, and poverty and the rising rate of illegitimacy in our society. "A vigorous (...) debate over these issues, which are of such pressing concern, is taking place now in our country. It largely concerns the means we should use to address them: What is the proper role of the government in solving these problems without depriving individuals of their right to shape their own destinies?" --from the Introduction by Andrew R. Cecil. (shrink)

This article will provide a critique of tworecent English marriage law decisions, thefirst concerning a (female to male) transgenderman and the second a (male to female)intersexed woman. It will do so throughconsideration of the dialogue between each andthe landmark transgender case of Corbett v. Corbett. It will highlight howboth decisions, in seeking to minimise the factof `departure' from Corbett, serve toreproduce key elements of that decision whichserve to undermine the future prospects fortransgender law reform in the English context.In particular, both (...) decisions, in differentways, or with different emphases, ensure that`legal sex' continues to be determined by(bio)logical and temporal factors. Crucially,however, as in Corbett, it is legalanxiety over the boundaries of the `natural',and the homophobia of law, that underscoresthis anxiety, that account for these particularconstructions of `legal sex'. (shrink)

Are qualia natural kinds? In order to give this question slightly more focus, and to show why it might be an interesting question, let me begin by saying a little about what I take qualia to be, and what natural kinds. For the purposes of this paper, I shall be assuming a fairly full-blooded kind of phenomenal realism about qualia: qualia, thus, include the qualitative painfulness of pain (rather than merely the functional specification of pain states), the qualitative redness in (...) the visual field that typically accompanies red discriminations, the taste of lemon (independently of the fact that such states are normally caused by lemons and give rise to puckering of the lips, etc.), and so on. In other words, I am assuming the falsity of functionalism with respect to qualia, though I am not for a moment assuming dualism. (shrink)

Qualia have historically been thought to stand in a very different epistemological relation to the knower than does the external furniture of the world. The ‘raw feels’ of thought were often said to be ‘given’, while what we might call the content of that thought – for example, claims about the external world – was thought only more or less doubtfully true; and this was often said to be because we are ‘directly’ or ‘non-inferentially’ confronted by qualia or experiences, whereas (...) all other properties or objects are only mediately ‘connected’ to the perceiver. The modern turn in philosophy – spearheaded by Wittgen-stein, Sellars, Quine, Ryle and others – away from classical empiricism to today’s ‘post-postivistic’ philosophy, has apparently involved the rejection of this once familiar assumption. I argue a) that the rejection of a certain kind of epistemological foundationalism does not entail the rejection of phenomenal individuals tout court; and b) that qualia are in fact, in some epistemologically significant ways, given. (shrink)